Computational Biology

Protein Bioinformatics

We provide protein sequence and structural bioinformatics services to research organizations, molecular biologists, clinical scientists and pharmaceutical companies. Protein sequence is heteropolymer made of 20 types of amino acids. Protein sequences are encoded in DNA of organisms and carries information about its unique 3D structure of molecular structure. Since protein structure determines its functions in an organism’s body, knowing or predicting structure from sequence can be very instrumental for scientists to study different situations under which protein may express itself. In this context, we provide valuable computational services to our clients, which include but not limited to the following;

  • Protein sequence analysis
  • Protein structure comparison
  • Pairwise and multiple protein sequence alignment
  • Homology modeling
  • Fold recognition
  • Ab initio modeling

Methods:

  • Statistical score functions
  • Sequence profiles
  • Monte Carlo simulations
  • Coarse grain force fields
  • Bayesian Classification

Tools:

  • FASTA, BLAST, PSI-BLAST, WURST, Dali, Rosetta, HHpred, MODELLER, TASSER